Elazar Z, Motles E, Simantov R
Electroencephalogr Clin Neurophysiol. 1981 Dec;52(6):640-6. doi: 10.1016/0013-4694(81)91438-3.
The influence of different body temperatures on the epileptiform discharges induced in hippocampus by local microinjections of leu-enkephalin was studied in rats. In the absence of enkephalin, changes in body temperature by either cooling or heating induced epileptiform discharges that disappeared after temperature stabilization. The epileptiform episode induced by enkephalin microinjections was of longer duration at temperature below normal (29-30 degrees C). At body temperature above normal (39-40 degrees C) the epileptiform discharge was less intense and of shorter duration. In vitro testing led to parallel results: the destruction of enkephalin by the brain tissue was faster at higher temperatures. It is proposed that in conditions of hyperthermia enkephalin has a weaker activity due to acceleration of the activity of peptidases involved in its breakdown.
研究了不同体温对局部微量注射亮氨酸脑啡肽诱导大鼠海马癫痫样放电的影响。在没有脑啡肽的情况下，通过冷却或加热引起的体温变化会诱发癫痫样放电，在体温稳定后放电消失。在低于正常体温（29 - 30摄氏度）时，脑啡肽微量注射诱发的癫痫样发作持续时间更长。在高于正常体温（39 - 40摄氏度）时，癫痫样放电强度较小且持续时间较短。体外试验得到了类似结果：在较高温度下，脑组织对脑啡肽的破坏更快。有人提出，在体温过高的情况下，由于参与脑啡肽分解的肽酶活性加速，脑啡肽的活性较弱。
