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哺乳动物毛囊生长期和退行期的外根鞘角化。毛囊中第七种独特的角化类型：毛小皮角化。

Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization.

作者信息

Pinkus H, Iwasaki T, Mishima Y

出版信息

J Anat. 1981 Aug;133(Pt 1):19-35.

PMID:6172407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1167722/
Abstract

Trichilemmal keratinization, first described in Maurer in 1895 and rediscovered by Holmes (1968) and Pinkus (1968) converts the stratified epithelium of the outer root sheath into anuclear keratin without an intervening keratohyalin layer. It is a distinct seventh type of keratinization in the hair follicle, not derived from the hair matrix. It occurs wherever outer root sheath is not apposed to inner root sheath, in anagen in the zone of sloughing just below the opening of the sebaceous duct, in catagen in the trichilemmal sac surrounding the lower end of the dying hair shaft where it forms the club of the telogen hair. Electron microscopic study of the thick hairs of dogs (but not the tiny hairs of rodents) reveals intricate infoldings of non-keratinized and keratinized cells. It also shows unique ladder-like membrane coating granules in anagen, which are strongly acid phosphatase-positive and are suggested to be the source of enzyme involved with disintegration of the inner root sheath.

摘要

毛鞘角化最初由毛雷尔于1895年描述，后由霍姆斯（1968年）和平库斯（1968年）重新发现，它将外根鞘的复层上皮转化为无核角蛋白，且无透明角质颗粒层的中间过渡。它是毛囊中一种独特的第七种角化类型，并非源自毛基质。它发生在外根鞘未与内根鞘相邻的任何部位，在生长期位于皮脂腺导管开口下方的脱落区，在退行期位于围绕即将死亡的毛干下端的毛鞘囊中，在此处形成休止期毛发的毛球。对狗的粗毛（而非啮齿动物的细毛）进行电子显微镜研究发现，非角化细胞和角化细胞有复杂的内褶。研究还显示，在生长期有独特的梯状膜包被颗粒，这些颗粒酸性磷酸酶呈强阳性，提示其为参与内根鞘分解的酶的来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/e4b7021e9035/janat00221-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/674a3f2941dc/janat00221-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/145f75742409/janat00221-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/a4262a7d22fa/janat00221-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/afe766354b62/janat00221-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/c8acf8662a30/janat00221-0031-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/1f1cdbb484d1/janat00221-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/c126059f3837/janat00221-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/d3df498a5e3b/janat00221-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/a61f06647da9/janat00221-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/ecab1d727ec6/janat00221-0035-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/a73014bdf697/janat00221-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/d67714e64a4a/janat00221-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/e4b7021e9035/janat00221-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/674a3f2941dc/janat00221-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/145f75742409/janat00221-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/a4262a7d22fa/janat00221-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/afe766354b62/janat00221-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/c8acf8662a30/janat00221-0031-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/1f1cdbb484d1/janat00221-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/c126059f3837/janat00221-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/d3df498a5e3b/janat00221-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/a61f06647da9/janat00221-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/ecab1d727ec6/janat00221-0035-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/a73014bdf697/janat00221-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/d67714e64a4a/janat00221-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8839/1167722/e4b7021e9035/janat00221-0041-a.jpg

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