Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea.
Molecular Genetics and Genomics Lab, Department of Horticulture, Chungnam National University, Daejeon 305-764, Republic of Korea.
Biomed Res Int. 2014;2014:319795. doi: 10.1155/2014/319795. Epub 2014 Nov 13.
Eclipta alba (L.) Hassk, Asiasarum sieboldii (Miq.) F. Maek (Asiasari radix), and Panax ginseng C. A. Mey (red ginseng) are traditionally acclaimed for therapeutic properties of various human ailments. Synergistic effect of each standardized plant extract was investigated for hair growth potential on nude mice, as these mutant mice genetically lack hair due to abnormal keratinization. Dried plant samples were ground and extracted by methanol. Topical application was performed on the back of nude mice daily up to completion of two hair growth generations. The hair density and length of Eclipta alba treated mice were increased significantly (P>0.001) than control mice. Hair growth area was also distinctly visible in Eclipta alba treated mice. On the other hand, Asiasari radix and Panax ginseng treated mice developing hair loss were recognized from the abortive boundaries of hair coverage. Histomorphometric observation of nude mice skin samples revealed an increase in number of hair follicles (HFs). The presence of follicular keratinocytes was confirmed by BrdU labeling, S-phase cells in HFs. Therefore, Eclipta alba extract and/or phytochemicals strongly displayed incomparability of hair growth promotion activity than others. Thus, the standardized Eclipta alba extract can be used as an effective, alternative, and complementary treatment against hair loss.
白花蛇舌草（L.）Hassk、石菖蒲（Miq.）F. Maek（Asiasari radix）和人参 C. A. 梅（红参）传统上被认为具有治疗各种人类疾病的特性。为了研究这些植物提取物的协同作用对无毛小鼠的毛发生长潜力，我们对这些突变小鼠进行了研究，因为这些突变小鼠由于角蛋白异常而遗传上缺乏毛发。将干燥的植物样品研磨并通过甲醇提取。每天在无毛小鼠的背部进行局部涂抹，直至完成两代毛发生长。与对照组相比，白花蛇舌草处理组的小鼠的毛发密度和长度显著增加（P>0.001）。在白花蛇舌草处理组的小鼠中也可以明显看到毛发生长区域。另一方面，从头发覆盖率的中断边界可以看出，在用石菖蒲和人参处理的小鼠中出现了脱发。无毛小鼠皮肤样本的组织形态学观察显示毛囊（HFs）数量增加。通过 BrdU 标记和 HFs 中的 S 期细胞证实了毛囊角质形成细胞的存在。因此，白花蛇舌草提取物和/或植物化学物质表现出了无与伦比的毛发生长促进活性。因此，标准化的白花蛇舌草提取物可作为脱发的有效、替代和补充治疗方法。
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