Trachtenberg J, Bujnovszky P, Walsh P C
J Clin Endocrinol Metab. 1982 Jan;54(1):17-21. doi: 10.1210/jcem-54-1-17.
In an effort to determine whether human benign prostatic hyperplasia (BPH) is characterized by an increase in androgen receptor content, the levels of nuclear and cytosolic androgen receptors were quantitated in normal prostatic tissue obtained from five young men (mean age /+- SEM, 26 +/- 3 yr) and in hyperplastic (periurethral) and peripheral prostatic tissues obtained from nine older men (mean age, 62 +/- 2 yr). There was no significant difference between the cytosolic or nuclear androgen receptor content of the hyperplastic, peripheral, or normal prostatic tissue. Thus, in this study we were unable to identify an increase in androgen receptor content in BPH. These findings fail to support the hypothesis that increases in androgen receptor content are involved in the pathogenesis of human BPH.
为了确定人类良性前列腺增生（BPH）是否具有雄激素受体含量增加的特征，对从5名年轻男性（平均年龄/±标准误，26±3岁）获取的正常前列腺组织以及从9名老年男性（平均年龄，62±2岁）获取的增生性（尿道周围）和外周前列腺组织中的核雄激素受体和胞质雄激素受体水平进行了定量分析。增生性、外周性或正常前列腺组织的胞质或核雄激素受体含量之间没有显著差异。因此，在本研究中，我们未能发现BPH中雄激素受体含量增加。这些发现不支持雄激素受体含量增加参与人类BPH发病机制的假说。
