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Possible phenylethylmalondiamide (PEMA) intoxication.

作者信息

Stern E L

出版信息

Ann Neurol. 1977 Oct;2(4):356-7. doi: 10.1002/ana.410020418.

DOI:10.1002/ana.410020418
PMID:617272
Abstract

We have encountered a case of apparent intoxication with primidone (Mysoline) in a patient with severe renal impairment. Of interest were high serum levels of phenylethyl-malondiamide (PEMA), a metabolite of primidone.

摘要

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引用本文的文献

1
Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration.
Clin Pharmacokinet. 1983 May-Jun;8(3):272-6. doi: 10.2165/00003088-198308030-00006.
2
Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men.
Eur J Clin Pharmacol. 1987;33(4):431-4. doi: 10.1007/BF00637644.
3
The disposition of primidone in elderly patients.扑米酮在老年患者中的处置情况。
Br J Clin Pharmacol. 1990 Oct;30(4):607-11. doi: 10.1111/j.1365-2125.1990.tb03820.x.
4
Primidone metabolism in renal insufficiency and acute intoxication.
J Neurol. 1979 Aug;221(2):101-4. doi: 10.1007/BF00313107.