Possible phenylethylmalondiamide (PEMA) intoxication.
作者信息
Stern E L
出版信息
Ann Neurol. 1977 Oct;2(4):356-7. doi: 10.1002/ana.410020418.
PMID:617272
Abstract
We have encountered a case of apparent intoxication with primidone (Mysoline) in a patient with severe renal impairment. Of interest were high serum levels of phenylethyl-malondiamide (PEMA), a metabolite of primidone.
摘要
相似文献
1
Possible phenylethylmalondiamide (PEMA) intoxication.
Ann Neurol. 1977 Oct;2(4):356-7. doi: 10.1002/ana.410020418.
2
Serum concentrations of primidone and its metabolites, phenylethylmalonamide and phenobarbital, in the dog.犬体内扑米酮及其代谢产物苯乙基丙二酰胺和苯巴比妥的血清浓度。
Am J Vet Res. 1980 Oct;41(10):1643-5.
3
Primidone metabolism in renal insufficiency and acute intoxication.
J Neurol. 1979 Aug;221(2):101-4. doi: 10.1007/BF00313107.
4
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
Ther Drug Monit. 1986;8(2):161-5. doi: 10.1097/00007691-198606000-00006.
5
The disposition of primidone in elderly patients.扑米酮在老年患者中的处置情况。
Br J Clin Pharmacol. 1990 Oct;30(4):607-11. doi: 10.1111/j.1365-2125.1990.tb03820.x.
6
Plasma level studies of primidone and its metabolites in the mouse at various stages of pregnancy.
Xenobiotica. 1977 Oct;7(10):617-22. doi: 10.3109/00498257709038683.
7
Clearance of phenylethylmalonamide during haemodialysis of a patient with renal failure.
Ther Drug Monit. 1990 May;12(3):281-3. doi: 10.1097/00007691-199005000-00012.
8
Intoxication with primidone: continuous monitoring of serum primidone and its metabolites during forced diuresis.
Neuropadiatrie. 1977 May;8(2):190-5. doi: 10.1055/s-0028-1091516.
9
Phenylethylmalonamide (PEMA). An important metabolite of primidone.
Arch Neurol. 1972 Jul;27(1):34-41. doi: 10.1001/archneur.1972.00490130036005.
10
Pharmacokinetics of phenylethylmalonamide (PEMA) in normal subjects and in patients treated with antiepileptic drugs.
Epilepsia. 1982 Jun;23(3):307-13. doi: 10.1111/j.1528-1157.1982.tb06196.x.
引用本文的文献
1
Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration.
Clin Pharmacokinet. 1983 May-Jun;8(3):272-6. doi: 10.2165/00003088-198308030-00006.
2
Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men.
Eur J Clin Pharmacol. 1987;33(4):431-4. doi: 10.1007/BF00637644.
3
The disposition of primidone in elderly patients.扑米酮在老年患者中的处置情况。
Br J Clin Pharmacol. 1990 Oct;30(4):607-11. doi: 10.1111/j.1365-2125.1990.tb03820.x.
4
Primidone metabolism in renal insufficiency and acute intoxication.
J Neurol. 1979 Aug;221(2):101-4. doi: 10.1007/BF00313107.
Zotero 插件