Yeary R A
Am J Vet Res. 1980 Oct;41(10):1643-5.
The elimination of primidone, phenylethylmalonamide, and phenobarbital (administered IV) was studied in dogs. The elimination half-lives were primidone, 1.85 +/- 0.3 (SEM) hours; phenylethylmalonamide, 7.1 +/- 1.45 hours; and phenobarbital, 40.9 +/- 4.96 hours. Dogs given repeated oral doses of primidone for 14 or 21 days had smaller primidone serum concentrations after each dosing. Dogs given 1.0 g of primidone orally (59.2 decreasing to 50.5 mg/kg of body weight) for 21 days accumulated the phenobarbital metabolite with apparent steady-state concentrations of 10 to 20 micrograms/ml and phenylethylmalonamide in concentrations of 2 to 5 micrograms/ml. Serum primidone concentrations decreased after repeated dosing and were measurable in only 1 dog 24 hours after the 21st dose and peak concentrations of 4 to 7 micrograms/ml were measured at 4 hours after the 22nd dose.
在犬类中研究了扑米酮、苯乙基丙二酰胺和苯巴比妥（静脉注射给药）的消除情况。消除半衰期分别为：扑米酮1.85±0.3（标准误）小时；苯乙基丙二酰胺7.1±1.45小时；苯巴比妥40.9±4.96小时。给予犬类重复口服扑米酮14天或21天，每次给药后扑米酮血清浓度均较低。给予犬类口服1.0 g扑米酮（体重从59.2 mg/kg降至50.5 mg/kg）21天，苯巴比妥代谢产物的表观稳态浓度为10至20μg/ml，苯乙基丙二酰胺浓度为2至5μg/ml。重复给药后血清扑米酮浓度降低，在第21次给药后24小时仅1只犬可检测到，第22次给药后4小时测得峰值浓度为4至7μg/ml。
