脂蛋白脂肪酶在大鼠心脏内源性三酰甘油调节中的可能作用。
Possible role of lipoprotein lipase in the regulation of endogenous triacylglycerols in the rat heart.
作者信息
Palmer W K, Caruso R A, Oscai L B
出版信息
Biochem J. 1981 Jul 15;198(1):159-66. doi: 10.1042/bj1980159.
Abstract
- Adrenaline has a biphasic effect on intracellular lipoprotein lipase activity and on endogenous triacylglycerol content in heparin-perfused heart. 2. A high concentration of adrenaline (1 microM in the perfusion buffer) activated endogenous lipoprotein lipase activity and, at the same time, decreased intracellular triacylglycerol stores. 3. In contrast, a low concentration (0.005 microM-adrenaline) inhibited intracellular lipoprotein lipase activity. Under these conditions, cardiac triacylglycerol content was elevated above control values. 4. Perfusing the heart with high and low concentrations of 3-isobutyl-1-methylxanthine elicited a biphasic effect on endogenous lipoprotein lipase activity and triacylglycerol content similar to that seen with adrenaline treatment. 5. The effect of adrenaline on intracellular lipoprotein lipase activity appears to be mediated by cyclic AMP through protein kinase. 6. A possible role for intracellular lipoprotein lipase in the regulation of endogenous triacylglycerol in rat heart is proposed.
摘要
- 肾上腺素对肝素灌注心脏中的细胞内脂蛋白脂肪酶活性和内源性三酰甘油含量具有双相作用。2. 高浓度肾上腺素（灌注缓冲液中为1微摩尔）激活内源性脂蛋白脂肪酶活性，同时降低细胞内三酰甘油储备。3. 相反，低浓度（0.005微摩尔肾上腺素）抑制细胞内脂蛋白脂肪酶活性。在这些条件下，心脏三酰甘油含量升高至对照值以上。4. 用高浓度和低浓度的3-异丁基-1-甲基黄嘌呤灌注心脏，对内源性脂蛋白脂肪酶活性和三酰甘油含量产生类似于肾上腺素处理所见的双相作用。5. 肾上腺素对细胞内脂蛋白脂肪酶活性的作用似乎是由环磷酸腺苷通过蛋白激酶介导的。6. 提出了细胞内脂蛋白脂肪酶在大鼠心脏内源性三酰甘油调节中的可能作用。
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