Crowell D H, Kapuniai L E, Boychuk R B, Light M J, Hodgman J E
Electroencephalogr Clin Neurophysiol. 1982 Jan;53(1):36-47. doi: 10.1016/0013-4694(82)90104-3.
Sleep monitoring at 3 months post term of clinically normal term infants, pre-term infants with no demonstrable pathologic clinical signs, and pre-term and term infants with a history of metabolic disorders show that these infants have EEG sleep stages resembling those seen in adults, as well as the adult pattern of sleep stage organization. The presence of NREM stage organization and stage sequencing suggest that sleep regulatory mechanisms are approaching a level of functional maturity in the human infant at 3 months post term. There is a significant relationship between sleep staging at 3 months post term and mental and motor performance at 12 months post term. In light of this, it is hypothesized that early bioelectric maturation may reflect the development of neural mechanisms which are also the substrate for later cognitive and behavioral functioning. Sleep stage organization at 3 months post term may be utilized as a benchmark of CNS development and for research on the pathophysiology of sleep disorders.
对足月临床正常的婴儿、无明显病理临床体征的早产儿以及有代谢紊乱病史的早产儿和足月儿在足月后3个月进行睡眠监测，结果显示这些婴儿的脑电图睡眠阶段与成年人相似，睡眠阶段组织模式也与成年人相同。非快速眼动睡眠阶段组织和阶段顺序的存在表明，足月后3个月的人类婴儿睡眠调节机制正接近功能成熟水平。足月后3个月的睡眠分期与足月后12个月的智力和运动表现之间存在显著关系。据此推测，早期生物电成熟可能反映了神经机制的发育，而神经机制也是后期认知和行为功能的基础。足月后3个月的睡眠阶段组织可作为中枢神经系统发育的基准以及睡眠障碍病理生理学研究的依据。
