The participation of trimethylammonium in the mouse erythrocyte epitope recognized by monoclonal autoantibodies.
作者信息
Serban D, Pages J M, Bussard A E, Witz I P
出版信息
Immunol Lett. 1981 Nov;3(5):315-9. doi: 10.1016/0165-2478(81)90012-2.
PMID:6173316
Abstract
Monoclonal IgM anti-erythrocyte autoantibody produced by a NZB-derived hybridoma has been found to react with trimethylammonium-containing compounds. Such compounds are able to prevent the lysis of bromelain-treated mouse erythrocytes (BrMRBC) by those autoantibodies. Using a column of insolubilized betaine hydrazine (BH) the monoclonal anti-erythrocyte antibody has been specifically retained. Elution of this antibody was accomplished by 0.15 M choline (Ch).
摘要
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