Yesavage J A, Tinklenberg J R, Hollister L E, Berger P A
J Am Geriatr Soc. 1982 Feb;30(2):105-8. doi: 10.1111/j.1532-5415.1982.tb01283.x.
In a single-blind study, 12 men (mean age 63 years) with senile dementia were given nafronyl in a dosage of 100 mg eight times daily for a week, followed by 100 mg four times daily for 12 weeks. Rigorous clinical, laboratory and psychometric assessments revealed no toxicity and no significant effects on vital functions. In the cerebrospinal fluid, the ratio of lactate to pyruvate decreased--a finding consistent with an increase in the aerobic metabolism of glucose.
在一项单盲研究中，12名患有老年痴呆症的男性（平均年龄63岁）服用了萘呋胺酯，剂量为每日8次，每次100毫克，持续一周，随后每日4次，每次100毫克，持续12周。严格的临床、实验室和心理测量评估显示没有毒性，对重要功能也没有显著影响。在脑脊液中，乳酸与丙酮酸的比率下降——这一发现与葡萄糖有氧代谢增加一致。
