经组织学证实的阿尔茨海默病痴呆患者腰椎脑脊液中的单胺代谢物浓度。
Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.
作者信息
Palmer A M, Sims N R, Bowen D M, Neary D, Palo J, Wikstrom J, Davison A N
出版信息
J Neurol Neurosurg Psychiatry. 1984 May;47(5):481-4. doi: 10.1136/jnnp.47.5.481.
Abstract
Concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxy indoleacetic acid (5-HIAA) and homovanillic acid (HVA) were determined in lumbar cerebrospinal fluid (CSF) from control subjects and patients of both presenile and senile age with histologically verified Alzheimer's dementia. CSF HVA increased with age in control but not in Alzheimer patients. HVA and 5-HIAA in the CSF of presenile Alzheimer patients was lower than that of age matched control subjects.
摘要
在对照受试者以及经组织学证实患有早老性和老年性阿尔茨海默病痴呆的患者的腰椎脑脊液（CSF）中，测定了3-甲氧基-4-羟基苯乙二醇（MHPG）、5-羟基吲哚乙酸（5-HIAA）和高香草酸（HVA）的浓度。对照受试者的脑脊液HVA随年龄增加，而阿尔茨海默病患者则不然。早老性阿尔茨海默病患者脑脊液中的HVA和5-HIAA低于年龄匹配的对照受试者。
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