Lewis大鼠实验性变应性脑脊髓炎的长期抑制：脂多糖的作用
Prolonged suppression of experimental allergic encephalomyelitis in the Lewis rats: the effect of lipopolysaccharides.
作者信息
Raziuddin S, Morrison D C
出版信息
J Immunol. 1982 Mar;128(3):1486-9.
PMID:6173441
Abstract
The current investigations have revealed that Lewis rats preimmunized with BP in CFA, and after recovery from the first episode of EAE, developed a second mild attack of EAE after challenge with BP/CFA at specified times. However, preimmunization of Lewis rats with BP complexed to LPS in CFA protects animals for a longer time from a second attack induced by BP/CFA challenge.
摘要
目前的研究表明，在完全弗氏佐剂（CFA）中用牛血清白蛋白（BP）预先免疫的Lewis大鼠，在首次实验性自身免疫性脑脊髓炎（EAE）发作恢复后，在特定时间用BP/CFA攻击会引发第二次轻度EAE发作。然而，在CFA中用与脂多糖（LPS）复合的BP预先免疫Lewis大鼠，可使动物在更长时间内免受BP/CFA攻击诱导的第二次发作。
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