Tanabe T, Yokota A, Yasuda K
Jpn Circ J. 1982 Feb;46(2):194-200. doi: 10.1253/jcj.46.194.
A series of 58 patients of aortitis syndrome were analyzed from the standpoint of the pathogenesis and surgical treatment. Investigations of HLA revealed a high incidence of HLA-A9, BW52, MT1 and DR2 antigens with statistically significant differences in the chi-square test. These data indicate that a haplotype composed of A9, BW52, MT1 and DR2 is common in patients with aortitis syndrome and suggest that a genetic factor plays an important role on the pathogenesis of the disease. Experiences with the surgical treatment of various types of aortitis syndrome, such as operation for cerebrovascular insufficiency (7 cases), for hypertension produced by coarctation or renovascular stenosis (14 cases), for aortic regurgitation (2 cases), and for aneurysm (7 cases) were analyzed. Reconstructive surgery is difficult in many of them because of the complicated lesion produced by inflammatory changes. Attention should be paid to the selection of the most suitable time for operation, application of special surgical technique, and prevention of the complications to obtain favorable results.
从发病机制和外科治疗的角度分析了58例主动脉炎综合征患者。对HLA的研究显示，HLA - A9、BW52、MT1和DR2抗原的发生率较高，卡方检验有统计学显著差异。这些数据表明，由A9、BW52、MT1和DR2组成的单倍型在主动脉炎综合征患者中很常见，并提示遗传因素在该疾病的发病机制中起重要作用。分析了各种类型主动脉炎综合征的外科治疗经验，如脑血管供血不足手术（7例）、缩窄或肾血管狭窄所致高血压手术（14例）、主动脉瓣关闭不全手术（2例）和动脉瘤手术（7例）。由于炎症改变导致病变复杂，其中许多患者的重建手术困难。应注意选择最合适的手术时机、应用特殊手术技术以及预防并发症，以获得良好效果。
