Werlin S L, Stefaniak J
Pediatr Res. 1982 Feb;16(2):123-5. doi: 10.1203/00006450-198202000-00009.
In contrast to morphologic maturity, the newborn rat pancreas is unresponsive to carbachol. At 24 h, carbachol-stimulated secretion of exportable proteins markedly increases. Responsiveness to the calcium ionophore, A23187, is present at term. At age 24 h, pancreas from fasted newborn rats is also unresponsive to carbachol. When cholecystokinin octapeptide or hydrocortisone was administered to fasted newborn rats secretory function developed normally. Thus, responsiveness of newborn rat pancreas to secretagogues matures rapidly and can be induced by hormones.
与形态成熟不同，新生大鼠的胰腺对卡巴胆碱无反应。在出生后24小时，卡巴胆碱刺激的可输出蛋白分泌显著增加。对钙离子载体A23187的反应在足月时就已存在。在出生后24小时，禁食新生大鼠的胰腺对卡巴胆碱也无反应。当向禁食新生大鼠注射八肽胆囊收缩素或氢化可的松时，分泌功能正常发育。因此，新生大鼠胰腺对促分泌剂的反应迅速成熟，并且可以由激素诱导。
