Häyry P, von Willebrand E, Ahonen J, Eklund B
Proc Eur Dial Transplant Assoc. 1981;18:367-74.
The majority of cadaveric kidney transplants suffer at most one rejection episode, thereafter the postoperative course is usually uneventful. The remaining transplants have repeated rejections terminating often in prolonged irreversible rejection and transplant removal. We have been curious about this difference and analysed whether the two types of grafts display equally the major histocompatibility (MHC) antigens on their surface. Using monospecific rabbit antisera to HLA-ABC and -DR and/or alloantisera directed to allelic determinants of HLA-A and -B, we were unable to demonstrate the MHC antigens in most of the 'well-functioning' kidneys whereas these antigens were almost regularly present on the vascular endothelial cells of transplants with repeated and irreversible rejections.
大多数尸体肾移植最多经历一次排斥反应，此后术后过程通常平稳。其余的移植则反复发生排斥反应，常常以长期不可逆的排斥反应和移植肾摘除告终。我们一直对这种差异感到好奇，并分析了这两种类型的移植物在其表面是否同样表达主要组织相容性（MHC）抗原。使用针对HLA - ABC和 - DR的单特异性兔抗血清和/或针对HLA - A和 - B等位基因决定簇的同种抗血清，我们在大多数“功能良好”的肾脏中未能证实MHC抗原的存在，而这些抗原几乎经常出现在发生反复且不可逆排斥反应的移植肾的血管内皮细胞上。
