Nix W L, Fernbach D J
Am J Pediatr Hematol Oncol. 1981 Winter;3(4):397-407.
The experience with myeloproliferative diseases (MPD) in children of a large pediatric hematology-oncology service during a 20-year period is reviewed. Twenty-seven patients with myeloproliferative diseases were treated, six with the juvenile type of chronic myelogenous leukemia (CML), 10 with the adult type of CML, three with familial MPD, one with unclassifiable MPD, and seven with acute leukemia in whom myelofibrosis was either a prodromal or terminal event. The literature is reviewed with particular emphasis regarding the relationships between the juvenile type of CML and monocytic leukemia, the adult type of CML and acute nonlymphocytic leukemia, and the relationship of myelofibrosis and myeloid metaplasia to the acute leukemias. New therapeutic approaches are needed in this heterogenous but interrelated group of disorders.
回顾了一家大型儿科血液肿瘤中心在20年期间儿童骨髓增殖性疾病（MPD）的治疗经验。共治疗了27例骨髓增殖性疾病患儿，其中6例为幼年型慢性粒细胞白血病（CML），10例为成人型CML，3例为家族性MPD，1例为无法分类的MPD，7例为急性白血病，骨髓纤维化在其中为前驱或终末事件。对相关文献进行了综述，特别强调了幼年型CML与单核细胞白血病、成人型CML与急性非淋巴细胞白血病之间的关系，以及骨髓纤维化和髓外化生与急性白血病的关系。在这组异质性但相互关联的疾病中需要新的治疗方法。
