Raghavan D, Peckham M J, Heyderman E, Tobias J S, Austin D E
Br J Cancer. 1982 Feb;45(2):167-73. doi: 10.1038/bjc.1982.29.
Prognostic factors have been studied in 59 men with clinical Stage I non-seminomatous germ-cell tumours of the testis (NSGCTT) seen at the Royal Marsden Hospital between 1973 and 1978. Fourteen of the patients relapsed, and 45 have remained continuously disease-free. Two factors were identified which showed a significant correlation with relapse following radiotherapy: local extent of the primary tumour, and rate of decline of serum alpha-foetoprotein (AFP) and beta-human chorionic gonadotrophin (hCG) levels following orchidectomy. High serum marker levels at the time of referral after orchidectomy were not prognostically significant per se. The presence of tissue-associated hCG in the primary tumour was not prognostically significant. The results were compared with histology and pathological stage of the primary tumour in patients presenting with lung metastases but no clinical evidence of lymph-node disease. Embryonal carcinoma was more commonly associated with a locally invasive primary tumour and with extralymphatic spread than was teratocarcinoma.
对1973年至1978年间在皇家马斯登医院就诊的59例临床I期睾丸非精原细胞瘤（NSGCTT）男性患者的预后因素进行了研究。14例患者复发，45例持续无病。确定了两个与放疗后复发显著相关的因素：原发肿瘤的局部范围，以及睾丸切除术后血清甲胎蛋白（AFP）和β-人绒毛膜促性腺激素（hCG）水平的下降速率。睾丸切除术后转诊时血清标志物水平高本身并无预后意义。原发肿瘤中组织相关hCG的存在并无预后意义。将结果与出现肺转移但无淋巴结疾病临床证据的患者的原发肿瘤组织学和病理分期进行了比较。与畸胎癌相比，胚胎癌更常与局部浸润性原发肿瘤和淋巴外扩散相关。
