精氨酸血管加压素对发作性睡病患者和症状性睡眠过度患者快速眼动睡眠的影响。
Effects of arginine vasotocin on REM sleep in narcoleptics and in symptomatic hypersomniacs.
作者信息
Popoviciu L, Corfariu O T, Tudosie M, Földes A, Pavel S
出版信息
Electroencephalogr Clin Neurophysiol. 1982 Mar;53(3):325-8. doi: 10.1016/0013-4694(82)90090-6.
Arginine vasotocin (AVT), in doses of 1.5 microgram, administered intranasally to two narcoleptics (a male aged 42 years and a female aged 35 years), as well as to 5 symptomatic hypersomniacs (3 females and 2 males), aged 25-57 years, induced very rapidly in most instances in sleep with REM periods at onset and markedly increased in amount of REM sleep during a fixed period of 180 min of sleep recording. After AVT administration there was a significant shortening of the time of occurrence of the first REM sleep period both in narcoleptics (t test = 0.05 greater than P greater than 0.025) and in symptomatic hypersomniacs (t test = 0.02 greater than P greater than 0.01).
向两名发作性睡病患者（一名42岁男性和一名35岁女性）以及5名症状性睡眠过多患者（3名女性和2名男性，年龄在25至57岁之间）经鼻内给予剂量为1.5微克的精氨酸血管加压素（AVT），在大多数情况下，给药后能非常迅速地诱导入睡并伴有快速眼动期，且在180分钟的固定睡眠记录期内快速眼动睡眠量显著增加。给予AVT后，发作性睡病患者（t检验=0.05，P大于0.025）和症状性睡眠过多患者（t检验=0.02，P大于0.01）首次快速眼动睡眠期出现的时间均显著缩短。
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