The effects of the specific uptake inhibitor Lu 10-171 (citalopram) upon brain indoleamine stores in the maturing mouse.

1. The specific 5-HT uptake inhibitor Lu 10-171 (Citalopram) was used to test uptake inhibition and reduced turnover in maturing mouse brain. 2. All ages showed 5-hydroxyindole acetic acid (5-HIAA) elevation indicative of inhibition and reduced turnover. Enzymatic blockade in conjunction with Lu 10-171 supported the evidence for reduced turnover. 3. The significance of early serotonergic maturation is discussed.