Goodrich C
Gen Pharmacol. 1983;14(5):525-7. doi: 10.1016/0306-3623(83)90113-1.
The effects of a single 20 mg/kg dose of citalopram (Lu 10-171) were studied in mice aged 1-10 days. Body temperature measured 2 and 24 hr after treatment was decreased in treated animals as compared with saline injected littermate controls. Two hours after treatment, temperature preference in a thermal gradient was unchanged in animals younger than 6 days; however, in animals 6 days or older, temperature preference was increased as compared with littermate controls. Twenty-four hours after treatment, temperature preference was increased in citalopram-treated animals at all ages tested. The results are discussed in relation to nervous system maturation.
研究了单次20mg/kg剂量的西酞普兰（Lu 10-171）对1至10日龄小鼠的影响。与注射生理盐水的同窝对照相比，治疗后2小时和24小时测量的体温在治疗组动物中降低。治疗后两小时，6日龄以下动物在热梯度中的温度偏好没有变化；然而，在6日龄及以上的动物中，与同窝对照相比，温度偏好增加。治疗后24小时，在所有测试年龄的西酞普兰治疗动物中温度偏好均增加。结合神经系统成熟对结果进行了讨论。
