多发性硬化症临床、神经生理学和免疫学参数的纵向研究。初步调查。

Longitudinal study of clinical, neurophysiological and immunological parameters in multiple sclerosis. Preliminary investigation.

作者信息

Gambi D, Rossini P M, Marchionno L, Ricci L, Barboni F, Di Primio R, Battista P

出版信息

Int J Tissue React. 1981 Dec;3(3-4):177-86.

Abstract

Thirty subjects affected with multiple sclerosis, of which 22 were female and eight male, with an average of 30 +/- 7, years were studied, for a period of 10-15 months,. clinically using Kurtzkes' report form, neurophysiologically (responses tested: VEP, BAEP, SEP, ESG) and immunologically (Rosette Et, Ea, EAC). Of the 30 cases, 19 showed poussées in the last three years and 11 were in the stabilization phase. The Kurtzke reports and the neurophysiological tests permitted an accurate assessment of lesion levels and their rate of evolution. The immunological tests showed a notable ability to differentiate between subjects with recent poussées and those in the stabilization phase presenting overall values significantly below the norm. In the follow-up, after treatments with methisoprinol, the immunological tests also revealed modifications of notable interest.

摘要

对30例多发性硬化症患者进行了研究，其中22例为女性，8例为男性，平均年龄30±7岁，研究时间为10 - 15个月。临床使用库茨克报告表，进行神经生理学（测试反应：视觉诱发电位、脑干听觉诱发电位、体感诱发电位、眼震电图）和免疫学（玫瑰花结Et、Ea、EAC）检查。30例病例中，19例在过去三年中有病情加重，11例处于稳定期。库茨克报告和神经生理学测试能够准确评估病变水平及其进展速度。免疫学测试显示出显著的能力，能够区分近期病情加重的患者和处于稳定期且总体值明显低于正常水平的患者。在随访中，使用美替诺醇治疗后，免疫学测试也显示出了值得关注的变化。