Likosky W, Elmore R S
Adv Neurol. 1982;32:535-40.
The EP is well demonstrated as a useful indicator of subclinical demyelinating disease. Our study performed on patients well defined as MS and monitored closely for clinical exacerbations demonstrated an unexpectedly high occurrence of significant worsening in EP parameters. These changes occurred in the presence or absence of clinical worsening. The parameter changes may represent new demyelination or other pathologic or neurophysiologic changes in neuropathologically static lesions.
诱发电位被充分证明是亚临床脱髓鞘疾病的一个有用指标。我们对明确诊断为多发性硬化症且密切监测临床病情加重情况的患者进行的研究表明，诱发电位参数出现显著恶化的发生率意外地高。这些变化在临床病情恶化或未恶化的情况下均会发生。参数变化可能代表神经病理学上静止性病变中的新的脱髓鞘或其他病理或神经生理学变化。
