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顺式二氯二氨铂与5-氮杂-2'-脱氧胞苷对小鼠白血病细胞的体内外协同作用。

Synergistic effect of cis-dichlorodiammineplatinum and 5-aza-2'-deoxycytidine on mouse leukemic cells in vivo and in vitro.

作者信息

Veselý J

出版信息

Int J Cancer. 1982 Jan 15;29(1):81-5. doi: 10.1002/ijc.2910290114.

DOI:10.1002/ijc.2910290114
PMID:6174463
Abstract

cis-Dichlorodiammineplatinum and 5-aza-2'-deoxycytidine display a considerable synergistic effect in L1210 and La mouse leukemia in vivo; the combination of both drugs is also clearly synergistic in vitro as evidenced by the effects on cell growth and cell survival in soft-agar medium. In exponential but not in stationary growth of L1210 cells, the drugs interfere with DNA and RNA synthesis.

摘要

顺式二氯二氨铂和5-氮杂-2'-脱氧胞苷在L1210和La小鼠白血病体内表现出显著的协同作用；两种药物的组合在体外也明显具有协同作用，这在软琼脂培养基中对细胞生长和细胞存活的影响中得到了证明。在L1210细胞的指数生长而非静止生长阶段，这两种药物会干扰DNA和RNA的合成。

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引用本文的文献

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Synergistic cell inactivation by cis-dichlorodiammineplatinum in combination with 1-propargyl-5-chloropyrimidin-2-one.
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