Insel T R, Murphy D L
J Clin Psychopharmacol. 1981 Sep;1(5):304-11. doi: 10.1097/00004714-198109000-00006.
This article reviews the literature concerning obsessive-compulsive disorder (OCD) and its treatment with drugs. We survey the differential diagnosis of OCD and the problems involved in evaluating its severity in a research setting. Pharmacological treatment of OCD has usually involved antidepressants, especially clomipramine, with equivocal but nevertheless encouraging success. Anxiolytic and neuroleptics have also been tried, but the results are inconsistent. We discuss the implications of these findings for treatment of patients with OCD and for future research.
本文综述了有关强迫症（OCD）及其药物治疗的文献。我们调查了强迫症的鉴别诊断以及在研究环境中评估其严重程度所涉及的问题。强迫症的药物治疗通常涉及抗抑郁药，尤其是氯米帕明，其效果虽不明确但仍令人鼓舞。也尝试过使用抗焦虑药和抗精神病药，但结果并不一致。我们讨论了这些发现对强迫症患者治疗及未来研究的意义。
