Walker E, Warner N L, Chesnut R, Kappler J, Marrack P
J Immunol. 1982 May;128(5):2164-9.
A series of H-2d B cell tumor lines and one monocytic tumor cell line were shown to be capable of I region-restricted antigen presentation to I-A-d- and I-Ed- restricted, antigen-specific cloned T cell hybridomas. For the most part, antigen presentation correlated with the present of Ia antigens on the presenting cells, although in a few interesting cases Ia-expression lines failed to present antigen. These T cell hybridomas, together with the B cell and to monocyte tumor cell lines, offer a unique set of tools to study the phenomenon of I region-restricted antigen presentation.
一系列H-2d B细胞肿瘤系和一个单核细胞肿瘤细胞系被证明能够将I区限制的抗原呈递给I-A-d和I-E-d限制的、抗原特异性的克隆T细胞杂交瘤。在大多数情况下，抗原呈递与呈递细胞上Ia抗原的存在相关，尽管在一些有趣的案例中，Ia表达系未能呈递抗原。这些T细胞杂交瘤，连同B细胞和单核细胞肿瘤细胞系，提供了一套独特的工具来研究I区限制的抗原呈递现象。
