Froebel K, Dickson R, Lewis D, Jasani M K, Sturrock R D
Ann Rheum Dis. 1984 Oct;43(5):703-9. doi: 10.1136/ard.43.5.703.
The phenomenon of increased spontaneous incorporation of 3H-thymidine (3H-TdR) into peripheral blood mononuclear cells in rheumatoid arthritis (RA) has been investigated. The activity was found to be short lived and affected less than 1% of cells. Using a Percoll density gradient we identified two populations of active cells. RA patients with active synovitis and increased 3H-TdR incorporation in the low density population of cells have higher overall 3H-TdR incorporation than normal controls and patients with inactive RA. The low density cell population is enriched for Ia+ cells. The data are consistent with raised spontaneous 3H-TdR incorporation being due to an in-vivo cell mediated immune response.
类风湿关节炎（RA）患者外周血单个核细胞中3H-胸腺嘧啶核苷（3H-TdR）自发掺入增加的现象已被研究。发现这种活性持续时间短，且影响不到1%的细胞。利用Percoll密度梯度，我们鉴定出了两个活性细胞群体。患有活动性滑膜炎且低密度细胞群体中3H-TdR掺入增加的RA患者，其总体3H-TdR掺入量高于正常对照组和非活动性RA患者。低密度细胞群体富含Ia+细胞。这些数据与体内细胞介导的免疫反应导致3H-TdR自发掺入增加是一致的。
