人类β样珠蛋白基因簇的一种新型重排。
A novel rearrangement of the human beta-like globin gene cluster.
作者信息
Trent R J, Bowden D K, Old J M, Wainscoat J S, Clegg J B, Weatherall D J
出版信息
Nucleic Acids Res. 1981 Dec 21;9(24):6723-33. doi: 10.1093/nar/9.24.6723.
Abstract
The first example of a duplication involving the human beta-like globin genes has been characterised in DNA from a native of Vanuatu. Restriction endonuclease mapping has shown that a 5 kb insert of DNA in the gamma-delta-beta gene cluster is due to duplication of the Ggamma-globin gene and results in a new rearrangement 5'-epsilon-Ggamma-Ggamma-Agamma-delta-beta-3'.
摘要
涉及人类类β珠蛋白基因的重复的首个实例已在来自瓦努阿图一名原住民的DNA中得到鉴定。限制性内切酶图谱分析表明，γ-δ-β基因簇中一段5 kb的DNA插入片段是由于Gγ珠蛋白基因的重复所致，并且产生了一种新的重排形式5'-ε-Gγ-Gγ-Aγ-δ-β-3'。
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