Chircu V, Ionescu M, Zgoanţă C
Med Interne. 1981 Oct-Dec;19(4):373-8.
Hematologic and immunochemical investigations carried out in 270 workers with chronic exposure to benzene demonstrated changes of the nucleologram and of the area of lymphocyte nucleoli as well as disorders of the humoral immune response revealed by radial immunodiffusion. The numerical rise of bi- and polynucleolated cells, of cells with irregular macronucleoli as well as an enlargement of the nucleolar area are assumed to reflect an increase of the endolymphocytic amounts of RNA. An increased capacity of immunoglobulin formation, particularly of IgM, was also observed. All these changes are considered as early signs of an enhanced immune reactivity following chronic exposure to benzene.
对270名长期接触苯的工人进行的血液学和免疫化学研究表明，核仁图和淋巴细胞核仁面积发生了变化，同时放射免疫扩散显示体液免疫反应出现紊乱。双核仁和多核仁细胞、具有不规则大核仁的细胞数量增加以及核仁面积增大，被认为反映了淋巴细胞内RNA含量的增加。还观察到免疫球蛋白形成能力增强，尤其是IgM。所有这些变化都被视为长期接触苯后免疫反应增强的早期迹象。
