Khristeva V, Mirchev N
Probl Khig. 1993;18:97-105.
On the basis of accumulated experience from the numerous investigations of the elements of the peripheral blood in workers of different areas in industry and agriculture a classification is made of the injuries of the blood system under chronic toxic effects. Results from the peripheral blood state of 200 workers with chronic exposure to benzol and other aromatic hydrocarbons are given, as well as for 155 agricultural workers in contact with pesticides for many years and 308 children of the region with polluted by heavy metals (mainly lead) environment. Attention is drawn, that both the acute intoxications and chronic toxic effects have provoking role for the manifestation of concealed congenital, not rarely genetically stimulated insufficiency of Gl-6-PHD, which is manifested clinically as haemolytic anemia and secretly proceeding hemoglobinopathies, which clinically develop as thalassemia at entering of toxic doses of drugs, heavy metals, pesticides in the organism.
根据对工农业不同地区工人外周血成分进行大量调查所积累的经验，对慢性毒性作用下血液系统的损伤进行了分类。给出了200名长期接触苯及其他芳烃工人的外周血状态结果，以及155名多年接触农药的农业工人和该地区308名生活在重金属（主要是铅）污染环境中的儿童的外周血状态结果。需要注意的是，急性中毒和慢性毒性作用对于隐匿性先天性（通常由遗传因素导致）葡萄糖-6-磷酸脱氢酶（Gl-6-PHD）不足的表现都具有诱发作用，这种不足在临床上表现为溶血性贫血，而隐匿性血红蛋白病在机体摄入毒性剂量的药物、重金属、农药时临床上会发展为地中海贫血。
