Burck U, Held K R, Kitschke H J, Carstensen M
Teratology. 1981 Oct;24(2):125-30. doi: 10.1002/tera.1420240203.
Fetal malformations may introduce complications of maternal pregnancy. A polyhydramnios represents one such complication during pregnancy. We want to report five abnormal pregnancies which were marked by acute polyhydramnios and/or premature labor due to an amniotic band syndrome associated with cerebral herniation in two cases, malignant oral teratoma in one case, bilateral cystic hygromas associated with generalized fetal hydrops in one case, and multiple internal malformations in one case alpha-fetoprotein (AFP) values between the 25th and 34th week of gestation were elevated 3.5 to 44 times the normal median value. Since all fetuses showed severe malformations incompatible with life our observations indicate the necessity to determine AFP in cases of acute polyhydramnios independent of the week of gestation. Conversely, elevated AFP levels in amniotic fluid obtained during prenatal diagnosis in the 16th week of gestation may also suggest rare fetal malformations outlined above.
胎儿畸形可能会引发母体孕期并发症。羊水过多就是孕期此类并发症之一。我们想要报告5例异常妊娠，其中2例因羊膜带综合征合并脑疝导致急性羊水过多和/或早产，1例因恶性口腔畸胎瘤，1例因双侧囊状水瘤合并胎儿全身水肿，1例因多种内脏畸形。妊娠第25至34周时甲胎蛋白（AFP）值升高至正常中位数的3.5至44倍。由于所有胎儿均显示出严重的、与生命不相容的畸形，我们的观察结果表明，在急性羊水过多的情况下，无论孕周如何，都有必要测定AFP。相反，在妊娠第16周产前诊断时获得的羊水中AFP水平升高，也可能提示上述罕见的胎儿畸形。
