Hemke G, Weise W
Zentralbl Gynakol. 1981;103(11):617-23.
Tests were applied to 118 out of 1,534 patients in a programme for alpha-fetoprotein analysis to compare values recorded from amniotic fluid with those obtained from maternal serum. The tests were part of a prenatal diagnosis scheme by which to rule genetic defects. Six clearly increased alpha-fetoprotein values which were indicators to malformations and admixture of fetal blood were recorded from amniotic fluid by means of Mancini's technique. No falsely negative findings were recordable. Only two values were increased in maternal serum, among them one falsely positive result with no malformation at all. The conclusion drawn from the above findings is that in the context of prenatal diagnosis of malformation the most reliable values are obtainable from determination of alpha-fetoprotein in amniotic fluid. Maternal serum tests may be recommended for screening for neural tube defects, with due reference to be made to upper limit values.
在一项甲胎蛋白分析项目中，对1534名患者中的118名进行了检测，以比较羊水检测值与母血检测值。这些检测是产前诊断方案的一部分，用于排除基因缺陷。通过曼西尼技术从羊水中记录到6个明显升高的甲胎蛋白值，这些值是胎儿畸形和胎儿血液混入的指标。未记录到假阴性结果。母血中只有两个值升高，其中一个是完全没有畸形的假阳性结果。从上述结果得出的结论是，在畸形产前诊断中，通过测定羊水中的甲胎蛋白可获得最可靠的值。母血检测可推荐用于神经管缺陷筛查，但需适当参考上限值。
