二甲基苯并(a)蒽诱导的大鼠乳腺肿瘤的拓扑分布。
Topographical distribution of dimethylbenz(a)anthracene-induced rat mammary tumors.
作者信息
Kellen J A
出版信息
Ann Clin Lab Sci. 1983 Jul-Aug;13(4):289-90.
PMID:6414359
Abstract
Intravenous administration of dimethylbenz(a)anthracene (DMBA) in the rat induces multiple mammary tumors. The nodules, benign or malignant, develop preferentially in the thoracic part of the milk line. Actinomycin D interferes with the carcinogenic action of DMBA, but it does not alter the regional distribution of the tumors formed. Evaluation of experimental data, using this tumor model, should take tumor topography into consideration.
摘要
给大鼠静脉注射二甲基苯并(a)蒽（DMBA）可诱发多发性乳腺肿瘤。这些结节，无论良性还是恶性，都优先在乳腺线上的胸部区域形成。放线菌素D会干扰DMBA的致癌作用，但不会改变所形成肿瘤的区域分布。使用这种肿瘤模型评估实验数据时，应考虑肿瘤的局部解剖位置。
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