Nauth H F, Böger A
Acta Cytol. 1982 Jan-Feb;26(1):1-6.
Smears were taken from vulvar skin in 203 cases (83 normal-appearing, 23 benign, 12 precancerous and 85 malignant conditions). Three cases were analyzed by electron microscopy. The appearance of dyskeratotic cells was regarded as a sign of malignancy; this was supported by ultrastructural study. Smears from normal vulvar skin revealed a high correlation between age and presence of nucleated keratinized squames, which occurred most often in the third and rarely in the eighth decade. Benign conditions showed cellular features like those of the normal vulva. In precancerous lesions, 58% of the smears showed dyskeratotic cells. Malignant conditions showed dyskeratotic cells in 66% of the smears and true cancer cells exclusively in an additional 14%. Our observations indicate that vulvar cytology can be a major diagnostic aid in all suspicious cases, especially in the elderly. Vulvar cytology cannot replace an exact histologic examination, but it can provide a reason for taking a biopsy earlier than might otherwise be the case.
对203例患者的外阴皮肤进行涂片检查（其中83例外观正常，23例为良性，12例为癌前病变，85例为恶性病变）。对3例进行了电子显微镜分析。角化不良细胞的出现被视为恶性肿瘤的标志；超微结构研究支持了这一点。正常外阴皮肤涂片显示，有核角化鳞状细胞的出现与年龄高度相关，多见于第三个十年，在第八个十年则很少见。良性病变的细胞特征与正常外阴相似。在癌前病变中，58%的涂片显示有角化不良细胞。恶性病变中，66%的涂片显示有角化不良细胞，另有14%仅显示真正的癌细胞。我们的观察表明，外阴细胞学检查可作为所有可疑病例的主要诊断辅助手段，尤其是对老年人。外阴细胞学检查不能替代精确的组织学检查，但它可以为比其他情况更早进行活检提供依据。
