Fuchs V, Coper H
Drug Alcohol Depend. 1980 May;5(5):367-77. doi: 10.1016/0376-8716(80)90162-3.
p-Chlorophenylalanine (p-CPA) reduces brain 5-hydroxytryptamine (5-HT) without altering the dopamine and norepinephrine content. Morphine does not influence the 5-HT level, but partly reverses the depletion of 5-HT by p-CPA. Morphine analgesia and toxicity are not affected by p-CPA treatment. p-CPA also has no effect on acute morphine hypothermia, but after chronic treatment of 5-HT-deficient mice the dose--response curve is no longer parallel, which suggests that another mode of morphine hypothermia occurs. p-CPA diminishes morphine-induced running after acute as well as after chronic morphine administration. p-CPA treatment reduces the sensitivity to the naloxone-precipitated withdrawal reaction, but does not affect the development of physical dependence.
对氯苯丙氨酸（p-CPA）可降低脑内5-羟色胺（5-HT）水平，而不改变多巴胺和去甲肾上腺素含量。吗啡不影响5-HT水平，但可部分逆转p-CPA所致的5-HT耗竭。p-CPA处理不影响吗啡镇痛和毒性。p-CPA对急性吗啡所致体温过低也无影响，但对5-HT缺乏小鼠进行慢性处理后，剂量-反应曲线不再平行，这提示吗啡导致体温过低存在另一种机制。急性和慢性给予吗啡后，p-CPA均可减少吗啡诱导的活动。p-CPA处理可降低对纳洛酮诱发的戒断反应的敏感性，但不影响身体依赖性的形成。
