Rosen A L, Gould S A, Sehgal L R, Sehgal H L, Rice C L, Rushing D, Moss G S
Crit Care Med. 1982 Apr;10(4):275-8. doi: 10.1097/00003246-198204000-00008.
Hemoglobin solutions have potential as temporary red cell substitutes. Their efficacy has been demonstrated by their ability to maintain life-supporting levels of O2 consumption and CO2 production in animals virtually free of red cells. They do not exhibit major toxic effects, but transient alterations in renal function remain a concern. Cardiac output does not increase in the face of acute anemia associated with isovolemic exchange transfusion with hemoglobin solution. However, cardiac reserve does not diminish significantly after infusion of hemoglobin solution. Alterations in production techniques may lead to a polymerized hemoglobin solution that has a hemoglobin concentration and P50 close to fresh whole blood. Though this development is encouraging, it is clear that no perfect red cell substitute currently is available.
血红蛋白溶液有作为临时红细胞替代品的潜力。它们的功效已通过其在几乎没有红细胞的动物中维持支持生命的氧气消耗水平和二氧化碳产生水平的能力得到证明。它们不会表现出重大毒性作用，但肾功能的短暂改变仍然是一个问题。面对与血红蛋白溶液等容交换输血相关的急性贫血时，心输出量不会增加。然而，输注血红蛋白溶液后心脏储备不会显著减少。生产技术的改变可能会导致一种聚合血红蛋白溶液，其血红蛋白浓度和P50接近新鲜全血。尽管这一进展令人鼓舞，但显然目前还没有完美的红细胞替代品。
