García Ramos J, Rodríguez Ortiz H, Eguía Lis M C
Acta Physiol Lat Am. 1977;27(4):147-56.
The cortical depression induced by the stimulation of some afferent fibers affects strychnine spikes elicited in two different ways: by direct electrical stimulation, and through the evoked potentials induced at the somatosensory area by single shocks to the radial nerve. The effects on these two types of responses were found to be very similar, which was taken to indicate that the site of action of the mechanism involved is the same, that is, the non-synaptic membranes of the dendrites of pyramidal neurons. It is suggested that the depressant action is mediated through the serotonergic neurons, since the previous administration of 5,6-Dihydroxytryptamine (5,6-DHT) blocked the changes. The 5-Hydroxytryptamine (5-HT) liberated would act as a neurohumoral agent, since the synaptic mechanisms do not seem to be involved and the effects are manifested in a diffuse manner.
某些传入纤维的刺激所诱发的皮质抑制，以两种不同方式影响士的宁峰电位：通过直接电刺激，以及通过对桡神经单次电击在体感区诱发的诱发电位。发现对这两种类型反应的影响非常相似，这表明所涉及机制的作用部位相同，即锥体神经元树突的非突触膜。有人提出，抑制作用是通过血清素能神经元介导的，因为预先给予5,6 - 二羟基色胺（5,6 - DHT）可阻断这些变化。释放的5 - 羟色胺（5 - HT）将作为一种神经体液因子起作用，因为似乎不涉及突触机制，且效应以弥漫方式表现出来。
