García Ramos J, de la Cerda E
Acta Physiol Lat Am. 1977;27(6):311-20.
The results of the electrical stimulation of the locus coeruleus in curarized cats, and the effects upon the observed cortical responses of 5,6-dihydroxytryptamine or 6-hydroxydopamine injected intracisternally or applied in the subarachnoideal space were studied. The changes were followed on the strychnine spikes produced after the topical application of this drug. Stimulation of the locus coeruleus elicited a response in every area of the cortex explored. The response was complex, showed a phase of depression and a phase of enhancement both mixed in different proportions. The depressant reaction was more marked with lower strengths of stimulation and the enhancement reactions appeared more evident with the stronger stimuli. Both these reactions were blocked by the previous administration of 6-hydroxydopamine and only the depressant one was practically abolished by 5,6-dihydroxytryptamine. It is concluded that a complex interaction exists between the noradrenergic neurons of the locus coeruleus and the serotonergic neurons, probably those of the raphe nuclei. It is suggested that the axons of the noradrenergic neurons in their way to the cortex, give off collaterals that innervate some serotonergic neurons. The monoamines liberated by these axon terminals at the cerebral cortex would act as neurohumoral agents.
研究了箭毒化猫中蓝斑电刺激的结果，以及向脑池内注射或蛛网膜下腔应用5,6 - 二羟基色胺或6 - 羟基多巴胺对观察到的皮层反应的影响。这些变化通过局部应用该药物后产生的士的宁棘波来跟踪。刺激蓝斑在探索的皮层各个区域均引发反应。该反应复杂，呈现出抑制期和增强期，二者以不同比例混合。刺激强度较低时，抑制反应更为明显；刺激强度较强时，增强反应更为显著。这两种反应均被预先给予的6 - 羟基多巴胺阻断，而5,6 - 二羟基色胺实际上仅消除了抑制反应。得出的结论是，蓝斑的去甲肾上腺素能神经元与5 - 羟色胺能神经元（可能是中缝核的神经元）之间存在复杂的相互作用。有人提出，去甲肾上腺素能神经元在其通向皮层的途中发出侧支，支配一些5 - 羟色胺能神经元。这些轴突终末在大脑皮层释放的单胺将作为神经体液因子起作用。
