Batt R A, Everard D M, Gillies G, Wilkinson M, Wilson C A, Yeo T A
J Reprod Fertil. 1982 Mar;64(2):363-71. doi: 10.1530/jrf.0.0640363.
Features of the reproductive axis in the genetically hypogonadal, obese mouse (genotype, ob/ob) were examined at 5-8 months of age and compared with those of wild-type litter mates. Hypothalamic concentrations of dopamine and 5-hydroxytryptamine were normal. Those of 5-hydroxyindoleacetic acid, noradrenaline and LH-RH were raised. LH-RH was biologically active. Pituitary concentration of LH was normal, but that of FSH was raised. Serum concentrations of LH and FSH, compared with those of wild-type animals, were normal and low, respectively. Gonad and accessory sex organs weights were reduced. These findings suggest that the release of FSH but not LH is defective in the ob/ob mouse. Preliminary in-vitro experiments indicated that the pituitary gland responded normally or even supernormally towards LH-RH in its release of LH. The defect in the reproductive axis of the obese mouse may be due to inadequate release of LH-RH although an insensitivity of the pituitary gland towards LH-RH in its release of FSH cannot be excluded.
对5至8月龄的遗传性性腺功能减退肥胖小鼠（基因型为ob/ob）的生殖轴特征进行了检测，并与野生型同窝小鼠的特征进行了比较。下丘脑多巴胺和5-羟色胺浓度正常。5-羟吲哚乙酸、去甲肾上腺素和促性腺激素释放激素（LH-RH）的浓度升高。LH-RH具有生物活性。垂体促黄体生成素（LH）浓度正常，但促卵泡生成素（FSH）浓度升高。与野生型动物相比，血清LH和FSH浓度分别正常和降低。性腺和附属生殖器官重量减轻。这些发现表明，ob/ob小鼠中FSH而非LH的释放存在缺陷。初步体外实验表明，垂体在释放LH时对LH-RH反应正常甚至超常。肥胖小鼠生殖轴的缺陷可能是由于LH-RH释放不足，尽管不能排除垂体在释放FSH时对LH-RH不敏感的可能性。
