Angel F, Schmalz P F, Morgan K G, Go V L, Szurszewski J H
Scand J Gastroenterol Suppl. 1982;71:71-5.
A preliminary report is presented of studies into the innervation of the canine muscularis mucosa. In vitro experiments have investigated the mechanical response to electrical stimulation and the release of gut peptides known to modulate gastrointestinal function. Exogenous substance P increased tone and amplitude of phasic contractions while neurotensin and vasoactive intestinal polypeptide (VIP) relaxed the muscularis mucosa. Immunoreactive VIP was released into the superfusate during transmural electrical stimulation of the antrum while VIP and substance P were present in superfusate from the colon. The significance of these findings has been discusses briefly.
本文给出了关于犬肌层黏膜神经支配研究的初步报告。体外实验研究了对电刺激的机械反应以及已知可调节胃肠功能的肠道肽的释放。外源性P物质增加了相性收缩的张力和幅度，而神经降压素和血管活性肠肽（VIP）则使肌层黏膜松弛。在胃窦的透壁电刺激过程中，免疫反应性VIP释放到灌流液中，而结肠灌流液中存在VIP和P物质。已简要讨论了这些发现的意义。
