Koch T R, Roddy D R, Carney J A, Go V L
Gastroenterology Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905.
Dig Dis Sci. 1988 Oct;33(10):1322-8. doi: 10.1007/BF01536686.
Concentrations of the candidate endocrine and paracrine peptide, peptide YY, were measured by specific radioimmunoassay in tissue extracts prepared from normal ileum, normal colon, Crohn's disease, and ulcerative colitis. In both the ascending and descending colon, there were significantly decreased mean concentrations of peptide YY in Crohn's colitis and ulcerative colitis, compared to mean concentrations in normal colon. There was no age-related decrease of concentrations of peptide YY in normal colon. The decrease in concentrations of peptide YY in colon obtained from patients with inflammatory bowel disease did not appear related either to the duration of the clinical symptoms of the disease or to the severity of colonic inflammation. Further studies of the physiological function of peptide YY in man are needed to determine whether these findings might be useful in understanding a component of the pathophysiology of idiopathic inflammatory bowel disease.
采用特异性放射免疫分析法，测定了从正常回肠、正常结肠、克罗恩病和溃疡性结肠炎组织提取物中候选内分泌和旁分泌肽——肽YY的浓度。在升结肠和降结肠中，与正常结肠的平均浓度相比，克罗恩结肠炎和溃疡性结肠炎中肽YY的平均浓度均显著降低。正常结肠中肽YY的浓度没有与年龄相关的下降。炎症性肠病患者结肠中肽YY浓度的降低似乎与疾病临床症状的持续时间或结肠炎症的严重程度均无关。需要对人体中肽YY的生理功能进行进一步研究，以确定这些发现是否有助于理解特发性炎症性肠病病理生理学的一个组成部分。
