Riska H, Pettersson T, Fröseth B, Klockars M
Acta Med Scand. 1982;211(1-2):45-50.
Beta 2 microglobulin (beta 2m) concentrations in serum and pleural fluid from 64 patients with pleural effusion were studied. The level of beta 2m in pleural fluid was generally twice that in serum. The ratio of pleural fluid beta 2m to serum beta 2m in patients groups defined according to the final diagnosis showed an interestingly high value in tuberculous pleuritis and in patients with rheumatoid arthritis with pleural effusion. There was a positive correlation between the beta 2m and lysozyme contents in pleural fluid, suggesting local and simultaneous activation of different cell lines when the pleura is involved. We suggest that pleural fluid and concomitant serum beta 2m measurements should be taken into consideration when pleural effusion of tuberculous origin is suspected. Furthermore, beta 2m determination might help to differentiate between rheumatoid pleural fluid and pleural involvement due to the other systemic diseases.
对64例胸腔积液患者的血清和胸液中的β2微球蛋白（β2m）浓度进行了研究。胸液中β2m的水平通常是血清中的两倍。根据最终诊断划分的患者组中，胸液β2m与血清β2m的比值在结核性胸膜炎以及伴有胸腔积液的类风湿关节炎患者中呈现出高得出奇的值。胸液中β2m与溶菌酶含量之间存在正相关，提示胸膜受累时不同细胞系的局部同时激活。我们建议，当怀疑为结核性胸腔积液时，应考虑检测胸液及同时检测血清β2m。此外，β2m测定可能有助于鉴别类风湿性胸液与其他全身性疾病所致的胸膜受累。
