Cilli V, Castrucci G
Boll Ist Sieroter Milan. 1981 Nov;60(5):355-68.
Several studies have been conducted on persistent infections induced by viruses which are usually lytic for the infected cells. At the onset of these infections at least four mechanisms seem to be involved, i.e., the defective interfering (DI) viral particles, the temperature-sensitive (ts) mutants, the interferon or the presence in the culture of integrated DNA proviral copies of RNA viruses. Actually these systems are very complex and their evolution could depend on several factors such as the type of virus, the growth temperature of the culture or the kind of culture. Beside the systems that have been discussed here there may be other still unknown factors which might be involved in persistent infections, both in vitro and in vivo. The discovery of these factors could eventually represent a realistic basis for a better understanding of the pathogenesis of slow virus diseases and also would offer the possibility to study the long-term reactions of the organism when subjected to vaccination with ts mutants.
已经针对通常对受感染细胞具有裂解性的病毒所诱导的持续性感染开展了多项研究。在这些感染开始时，似乎至少涉及四种机制，即缺陷干扰（DI）病毒颗粒、温度敏感（ts）突变体、干扰素或培养物中存在RNA病毒的整合DNA原病毒拷贝。实际上，这些系统非常复杂，其演变可能取决于多种因素，如病毒类型、培养物的生长温度或培养类型。除了这里讨论的系统之外，可能还有其他尚不清楚的因素参与体外和体内的持续性感染。这些因素的发现最终可能为更好地理解慢病毒疾病的发病机制提供现实依据，也将为研究机体在用ts突变体进行疫苗接种时的长期反应提供可能性。
