Jerant-Patić Vera
Med Pregl. 2008 Jul-Aug;61(7-8):319-26.
Viral injections are the most common human diseases (especiaily acute respiratory infections, mostly in children and young adults). The current studies show that viral infections can cause not only acute, but persistent viral diseases as well. A certain number of viruses are able to incorporate their nucleic acid into the genome of the host-cell, leading to rearrangement of the cell genes and formation of malignant tumors. Viral persistence can cause manifiestations of latent or chronic infections, as well as prion-caused slow infections of the central nervous system. Defective Di particles play an important role in maintaining viral persistence. Viruses are important agents involved in various disorders of the immunological homeostasis of the organism. Newly-found viruses represent a special problem.
病毒感染是最常见的人类疾病(尤其是急性呼吸道感染,主要发生在儿童和年轻人中)。目前的研究表明,病毒感染不仅会导致急性疾病,还会引发持续性病毒疾病。一定数量的病毒能够将其核酸整合到宿主细胞的基因组中,导致细胞基因重排并形成恶性肿瘤。病毒的持续性可导致潜伏或慢性感染的表现,以及朊病毒引起的中枢神经系统慢感染。缺陷型Di颗粒在维持病毒持续性方面发挥着重要作用。病毒是参与机体免疫稳态各种紊乱的重要因素。新发现的病毒是一个特殊问题。