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部分射精功能不全:口服活性选择性α-肾上腺素能受体激动剂米多君的治疗效果

Partial ejaculatory incompetence: the therapeutic effect of midodrine, an orally active selective alpha-adrenoceptor agonist.

作者信息

Riley A J, Riley E J

出版信息

Eur Urol. 1982;8(3):155-60. doi: 10.1159/000473504.

DOI:10.1159/000473504
PMID:6176452
Abstract

The syndrome of partial ejaculatory incompetence has been reviewed. 6 patients, diagnosed as suffering from partial ejaculatory incompetence, were studied. For each subject, large numbers of spermatozoa were present in the post-masturbation urine sample providing evidence of disturbed ejaculatory function. The effect of a potent alpha-adrenoceptor agonist (Midodrine) was evaluated in these patients by means of a double-blind crossover study. Active treatment resulted in a significant increase in intensity of orgasmic sensation, and in a statistically significant improvement in ejaculatory function.

摘要

对部分射精功能不全综合征进行了综述。研究了6例被诊断为部分射精功能不全的患者。对于每个受试者,手淫后尿液样本中存在大量精子,这为射精功能紊乱提供了证据。通过双盲交叉研究评估了一种强效α-肾上腺素能受体激动剂(米多君)对这些患者的作用。积极治疗导致性高潮感觉强度显著增加,射精功能在统计学上有显著改善。

相似文献

1
Partial ejaculatory incompetence: the therapeutic effect of midodrine, an orally active selective alpha-adrenoceptor agonist.部分射精功能不全:口服活性选择性α-肾上腺素能受体激动剂米多君的治疗效果
Eur Urol. 1982;8(3):155-60. doi: 10.1159/000473504.
2
Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study.米多君用于脊髓损伤和射精障碍患者:一项双盲随机安慰剂对照试验性研究。
J Spinal Cord Med. 2015 Jan;38(1):57-62. doi: 10.1179/2045772314Y.0000000225. Epub 2014 Jun 26.
3
[Treatment of ejaculation disorders by midodrine (Gutron) per os. Retrospective study of about 16 subjects].
Ann Readapt Med Phys. 2005 Feb;48(1):34-40. doi: 10.1016/j.annrmp.2004.09.004.
4
The use of Midodrin in the treatment of ejaculation disorders following retroperitoneal lymphadenectomy.米多君在治疗腹膜后淋巴结清扫术后射精功能障碍中的应用。
Eur Urol. 1979;5(3):184-7. doi: 10.1159/000473102.
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Midodrine for the treatment of organic anejaculation but not spinal cord injury: a prospective randomized placebo-controlled double-blind clinical study.米多君治疗器质性不射精而非脊髓损伤:一项前瞻性随机安慰剂对照双盲临床研究。
Int J Impot Res. 2009 Jul-Aug;21(4):213-20. doi: 10.1038/ijir.2009.19. Epub 2009 May 28.
6
The alpha-sympathomimetic midodrin as a tool for diagnosis and treatment of sperm transport disturbances.α-拟交感神经药米多君作为诊断和治疗精子运输障碍的一种手段。
Andrologia. 1994 Sep-Oct;26(5):283-7. doi: 10.1111/j.1439-0272.1994.tb00803.x.
7
Treatment of retrograde ejaculationin paraplegia.截瘫患者逆行射精的治疗
Andrologia. 1980 Jul-Aug;12(4):389-90.
8
[Treatment of retrograde ejaculation and anorgasm with an alpha-sympathomimetic agent (Midodrin)].用一种α-拟交感神经药(米多君)治疗逆行射精和性高潮缺失
Z Hautkr. 1980 Jun 1;55(11):756-9.
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[Conservative therapy of female stress incontinence. Double-blind study with the alpha-sympathomimetic midodrin].
Fortschr Med. 1984 May 24;102(20):578-80.
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Inhibition of Seminal emission is the main cause of anejaculation induced by a new highly selective alpha1A-blocker in normal volunteers.在正常志愿者中,抑制射精是一种新型高选择性α1A阻滞剂所致不射精的主要原因。
J Sex Med. 2008 Sep;5(9):2185-90. doi: 10.1111/j.1743-6109.2008.00779.x. Epub 2007 Apr 9.

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Crit Care Resusc. 2023 Oct 16;24(4):298-308. doi: 10.51893/2022.4.R. eCollection 2022 Dec 5.
2
Retrospective review on effectiveness of high-amplitude penile vibratory stimulation for conservative sperm retrieval in anejaculatory men with spinal cord injury: an Asian case series.高振幅阴茎振动刺激对脊髓损伤所致不射精男性进行保守性取精的有效性回顾性研究:一项亚洲病例系列研究
Spinal Cord Ser Cases. 2016 Apr 7;2:15038. doi: 10.1038/scsandc.2015.38. eCollection 2016.
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Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients.
支持针对慢性脊髓损伤患者的中枢模式发生器调节疗法进行临床开发的临床前证据。
Front Hum Neurosci. 2014 May 30;8:272. doi: 10.3389/fnhum.2014.00272. eCollection 2014.
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Retarded ejaculation in men: an overview of psychological and neurobiological insights.
World J Urol. 2005 Jun;23(2):76-81. doi: 10.1007/s00345-004-0487-8. Epub 2005 Jun 4.
5
Disorders of ejaculation.射精障碍
J Endocrinol Invest. 2002 Dec;25(11):1006-19. doi: 10.1007/BF03344077.