Köhn F M, Schill W B
Department of Dermatology and Andrology, Justus Liebig University, Giessen, Germany.
Andrologia. 1994 Sep-Oct;26(5):283-7. doi: 10.1111/j.1439-0272.1994.tb00803.x.
The present study was performed to determine the usefulness of the alpha-sympathomimetic midodrin for diagnosis and treatment of functional sperm transport disturbances. 140 andrological patients consulting due to severe oligozoospermia, hypospermia or partial/complete retrograde ejaculation were included. Ejaculates were examined 30 min after intravenous injection of 5-15 mg midodrin. Sperm concentration, motility and alpha-glucosidase as a marker of both epididymal function and sufficient passage through the vasa deferentia and the ejaculatory duct were measured and the values compared to those in the ejaculates obtained before therapy. In 23 of 140 patients, sperm concentration or total sperm count was improved by more than 10 million spermatozoa ml-1 or 20 million spermatozoa per ejaculation. Alpha-glucosidase in the seminal plasma increased in two cases. The present study demonstrates that severe oligozoospermia may be caused by functional transport disturbance of semen from the epididymis to the efferent duct system. In these cases, midodrin is of diagnostic and therapeutic value; however, it should be emphasized that its effectiveness cannot be predicted individually.
本研究旨在确定α-拟交感神经药米多君对功能性精子运输障碍的诊断和治疗价值。纳入了140例因严重少精子症、精子减少症或部分/完全逆行射精前来咨询的男科患者。静脉注射5 - 15毫克米多君30分钟后检查射精情况。测量精子浓度、活力以及作为附睾功能和通过输精管及射精管充分运输标志的α-葡萄糖苷酶，并将这些值与治疗前获得的射精样本中的值进行比较。在140例患者中的23例中，精子浓度或总精子数每毫升增加超过1000万个精子或每次射精增加超过2000万个精子。精浆中的α-葡萄糖苷酶在两例中有所增加。本研究表明，严重少精子症可能由精液从附睾到输出管道系统的功能性运输障碍引起。在这些情况下，米多君具有诊断和治疗价值；然而，应该强调的是，其有效性无法个体预测。
