Gmür J, Baumberger U, von Felten A
Schweiz Med Wochenschr. 1976 Oct 2;106(40):1358-9.
80 platelet transfusions from 38 different "full-house" HLA-typed single donors (10 siblings, 28 unrelated persons) were given to 14 thrombocytopenic patients refractory to platelets from random donors. The transfusions resulted in increased platelet increments, provided that the donor had no additional HLA-specificities whatsoever. In 14 out of 19 situations of not-identity between donor and recipient and with poor posttransfusion platelet increments, lymphocytotoxicity tests (incubation of 180 min at room temperature) were positive. This test therefore appears to be a useful tool in predicting the outcome of the transfusions. Granulocytotoxicity tests were positive in 4 HLA-identical donor-recipient pairs. Although severe transfusion reactions were observed, no detrimental influence on platelet increments could be found.
将来自38位不同的“HLA全相合”单采供血者（10位同胞、28位非亲属）的80次血小板输注给予14例对随机供血者血小板难治的血小板减少症患者。如果供血者没有任何额外的HLA特异性，则输注会使血小板增加值增加。在供血者与受血者不相合且输血后血小板增加值不佳的19种情况中的14种，淋巴细胞毒性试验（室温孵育180分钟）呈阳性。因此，该试验似乎是预测输血结果的有用工具。在4对HLA相合的供血者-受血者中，粒细胞毒性试验呈阳性。虽然观察到严重的输血反应，但未发现对血小板增加值有不利影响。
