对黄病毒的基因控制抗性的干扰素非依赖性
Interferon independence of genetically controlled resistance to flaviviruses.
作者信息
Brinton M A, Arnheiter H, Haller O
出版信息
Infect Immun. 1982 Apr;36(1):284-8. doi: 10.1128/iai.36.1.284-288.1982.
Abstract
Flavivirus-resistant C3H/RV mice injected with sheep anti-interferon globulin and then infected with either West Nile or yellow fever virus survived and displayed no disease symptoms. Also, treatment of embryo fibroblast cultures prepared from C3H/RV or congenic susceptible C3H/HE mice with anti-interferon serum resulted in an increased yield of West Nile virus from both types of cultures, but the amount of infectious virus produced by resistant cultures remained 1 to 1.5 logs lower than that produced by susceptible cell cultures. These results indicate that the mode of expression of the flavivirus resistance gene differs significantly from that of the Mx gene conferring resistance to influenza virus-induced disease in A2G mice.
摘要
给抗黄病毒的C3H/RV小鼠注射羊抗干扰素球蛋白，然后用西尼罗河病毒或黄热病病毒感染，这些小鼠存活下来且未表现出疾病症状。此外，用抗干扰素血清处理由C3H/RV或同基因易感的C3H/HE小鼠制备的胚胎成纤维细胞培养物，两种培养物中产生的西尼罗河病毒产量均增加，但抗性培养物产生的感染性病毒量仍比易感细胞培养物产生的低1至1.5个对数。这些结果表明，黄病毒抗性基因的表达模式与赋予A2G小鼠抗流感病毒诱导疾病的Mx基因的表达模式有显著差异。
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