羊膜的通透性及其在移植方面的潜在应用。

Permeability of the amniotic membrane and its potential application for transplantation purposes.

作者信息

Akle C A, Adinolfi M, McColl I

出版信息

Int J Biol Res Pregnancy. 1981;2(1):23-7.

Abstract

Uncertainty still exists as to the immunologic and physiologic properties of human amnion. It is clear, however, that these cells have a unique function and ultrastructure and may lack histocompatibility antigens. This raises the possibility of using the amnion for the replacement of a defective tissue or to protect an incompatible graft. In addition, the amniotic epithelial cells could be used to treat patients with inborn errors of metabolism. With this in mind, we have investigated the in vitro transfer of a number of compounds across the human amniotic membrane and furthermore have assessed the suitability of the amnion for transplantation purposes in an experimental model.

摘要

关于人羊膜的免疫和生理特性仍存在不确定性。然而，很明显这些细胞具有独特的功能和超微结构，并且可能缺乏组织相容性抗原。这增加了使用羊膜替代有缺陷组织或保护不相容移植物的可能性。此外，羊膜上皮细胞可用于治疗先天性代谢缺陷患者。考虑到这一点，我们研究了多种化合物在体外透过人羊膜的转运情况，并且进一步评估了羊膜在实验模型中用于移植目的的适用性。