Fagbemi O, Kane K A, Parratt J R
J Cardiovasc Pharmacol. 1982 Jan-Feb;4(1):53-8. doi: 10.1097/00005344-198201000-00009.
The effects of various doses of creatine phosphate have been examined in a rat model of acute myocardial ischaemia. When given directly into the lumen of the left ventricle in pentobarbitone-anaesthetised male rats, creatine phosphate (50 and 100 mg/kg) markedly reduced the incidence of ventricular ectopic beats, and especially the incidence and duration of ventricular tachycardia and fibrillation which normally resulted from acute coronary artery ligation in this model. This protection was observed even if 1 of 2 h elapsed between creatine phosphate administration and coronary artery ligation. Electrophysiological studies on papillary muscles removed from rats 1 h after administration showed that creatine phosphate both decreased the maximum rate of depolarisation and prolonged the duration of the action potential. These results confirm our previous work in dogs that creatine phosphate is effective against early postinfarction ventricular arrhythmias, at least if given locally. It is suggested that these effects are due, at least in part, to a prolongation of the cardiac muscle action potential. Whether this is the result of maintaining energy production early in myocardial ischaemia is unclear.
已在急性心肌缺血大鼠模型中研究了不同剂量磷酸肌酸的作用。在戊巴比妥麻醉的雄性大鼠中，将磷酸肌酸（50和100mg/kg）直接注入左心室腔时，可显著降低室性早搏的发生率，尤其是该模型中急性冠状动脉结扎通常导致的室性心动过速和颤动的发生率及持续时间。即使在给予磷酸肌酸与冠状动脉结扎之间间隔1或2小时，仍可观察到这种保护作用。给药1小时后从大鼠身上取出乳头肌进行电生理研究表明，磷酸肌酸既能降低最大去极化速率，又能延长动作电位的持续时间。这些结果证实了我们之前在犬类身上的研究，即磷酸肌酸至少在局部给药时对梗死早期室性心律失常有效。提示这些作用至少部分归因于心肌动作电位的延长。这是否是在心肌缺血早期维持能量产生的结果尚不清楚。
