乳腺癌患者的生化评估。
Biochemical evaluation of patients with breast cancer.
作者信息
Lee Y T, Haymond H R, Feder B
出版信息
J Surg Oncol. 1982 Apr;19(4):197-200. doi: 10.1002/jso.2930190404.
Peripheral blood specimens were obtained from 50 patients with various stages of breast cancer (I-II = 7, III = 6, IV = 24, treated and NED = 13), and 20 biochemical tests were performed. There are significant differences of hemoglobin, LDH, SGPT, serum protein, albumin, and alpha globulin values between patients with early (I, II, NED) and late (III, IV) lesions. Among patients with stage IV diseases, those patients with bony metastases had significantly higher values of alkaline phosphatase, alpha-1 globulin, IgA, and C-reactive protein than those with nonosseous lesions. Neither CEA nor pregnancy-associated alpha-2 glycoprotein showed any correlation with different stages or sites of breast cancer in these small series of patients.
从50例处于不同阶段乳腺癌患者（I-II期=7例，III期=6例，IV期=24例，接受治疗且无疾病证据=13例）获取外周血标本，并进行了20项生化检测。早期（I、II、无疾病证据）和晚期（III、IV）病变患者之间的血红蛋白、乳酸脱氢酶、谷丙转氨酶、血清蛋白、白蛋白和α球蛋白值存在显著差异。在IV期疾病患者中，有骨转移的患者碱性磷酸酶、α-1球蛋白、IgA和C反应蛋白的值显著高于无骨病变的患者。在这一小系列患者中，癌胚抗原和妊娠相关α-2糖蛋白均与乳腺癌的不同阶段或部位无任何相关性。
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